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| 5-Hydroxytryptophan |  |
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| Several OTC herbal supplements containing 5-hydroxytryptophan (5-HTP) or Griffonia seed extracts claim to treat depression, headaches, insomnia, and obesity. Orally, 5-HTP is rapidly absorbed and constitutively converted to serotonin (5-hydroxytryptamine). In cases of 5-HTP overdose, excessive concentrations of serotonin at target cells (GI, CNS, cardiovascular, and respiratory systems) can lead to a serotonin-like syndrome in dogs (eg, seizures, depression, tremors, ataxia, vomiting, diarrhea, hyperthermia, transient blindness, and death). Clinical signs can develop within 4 hr after ingestion and last up to 36 hr. Treatment consists of early decontamination, control of CNS signs (diazepam, barbiturates), thermoregulation (cool water bath, fans), fluid therapy, and administration of a serotonin antagonist such as cyproheptadine (1.1 mg/kg, PO or rectally). |
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| See Also |
| Toxicities from Over-the-counter Drugs |
| Overview |
| Cold and Cough Medications |
| Antihistamines |
| Decongestants |
| Imidazoline Decongestants |
| Pseudoephedrine and Ephedrine |
| Analgesics |
| Nonsteroidal Anti-inflammatory Drugs (NSAID) |
| Gastrointestinal Drugs |
| H2 -Receptor Antagonists |
| Antacids |
| Multivitamins and Iron |
| Topical Preparations |
| Zinc Oxide |
| Nutritional Supplements |
| Ma Huang (Ephedrine) and Guarana (Caffeine) |
| Toxicities from Prescription Drugs |
| Overview |
| Cardiovascular medications |
| Overview |
| Angiotensin-converting Enzyme (ACE) Inhibitors |
| Calcium Channel Blockers |
| β Blockers |
| Diuretics |
| Tranquilizers, Antidepressants, sleep Aids, and Anticonvulsants |
| Overview |
| Benzodiazepines |
| Antidepressants |
| Barbiturates |
| Sleep Aids |
| Phenothiazine Tranquilizers |
| Muscle Relaxants |
| Topical Agents |
| Overview |
| 5-Fluorouracil |
| Calcipotriene |
| Prescription nonsteroidal Anti-inflammatory Drugs |
| Overview |
| Carprofen |
| Etodolac |
| Deracoxib |
| Toxicities from Illicit and Abused Drugs |
| Overview |
| Cocaine |
| Amphetamines and Related Drugs |
| Marijuana (Cannabis) |
| Opiates |
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