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| Etodolac |  |
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| Etodolac is an indole acetic acid-derivative NSAID labeled for use in dogs to treat pain and inflammation associated with osteoarthritis. It is rapidly absorbed orally, with peak serum concentrations seen 2 hr after dosing. It is primarily eliminated through the bile. The elimination half-life is 8-12 hr. Etodolac appears to be well tolerated by dogs when used at the labeled dosage (10-15 mg/kg, PO, sid) for 1 yr. With multiple doses, clinical signs of toxicity such as GI ulcers, vomiting, diarrhea, and weight loss can be seen at 40 mg/kg. Six of 8 dogs died or became moribund due to GI ulceration at 80 mg/kg. |
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| See Also |
| Toxicities from Over-the-counter Drugs |
| Overview |
| Cold and Cough Medications |
| Antihistamines |
| Decongestants |
| Imidazoline Decongestants |
| Pseudoephedrine and Ephedrine |
| Analgesics |
| Nonsteroidal Anti-inflammatory Drugs (NSAID) |
| Gastrointestinal Drugs |
| H2 -Receptor Antagonists |
| Antacids |
| Multivitamins and Iron |
| Topical Preparations |
| Zinc Oxide |
| Nutritional Supplements |
| Ma Huang (Ephedrine) and Guarana (Caffeine) |
| 5-Hydroxytryptophan |
| Toxicities from Prescription Drugs |
| Overview |
| Cardiovascular medications |
| Overview |
| Angiotensin-converting Enzyme (ACE) Inhibitors |
| Calcium Channel Blockers |
| β Blockers |
| Diuretics |
| Tranquilizers, Antidepressants, sleep Aids, and Anticonvulsants |
| Overview |
| Benzodiazepines |
| Antidepressants |
| Barbiturates |
| Sleep Aids |
| Phenothiazine Tranquilizers |
| Muscle Relaxants |
| Topical Agents |
| Overview |
| 5-Fluorouracil |
| Calcipotriene |
| Prescription nonsteroidal Anti-inflammatory Drugs |
| Overview |
| Carprofen |
| Deracoxib |
| Toxicities from Illicit and Abused Drugs |
| Overview |
| Cocaine |
| Amphetamines and Related Drugs |
| Marijuana (Cannabis) |
| Opiates |
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